Joe Clarke picked up two catches and scored a quickfire 27 as The North again tasted defeat in the second 50 over match against The South in Dubai.
The Worcestershire wicket-keeper batsman was soon in the action as he held onto a nick from Daniel Bell-Drummond after an attempted drive off Tim Bresnan without a run on the board.
That was the first wicket the South had lost in the series after Dawid Malan and Bell-Drummond sealed a 10-wicket win on Thursday.
This time the South the went onto amass 346-6 in their 50 overs after being put into bat and The North were restricted to 299-9 in reply.
Clarke's second success behind the wicket came when Malan (78) – a century-maker in the first game – edged a delivery from Jack Leaning.
Sam Northeast hit an unbeaten 118 off 104 balls with one six and 12 fours in front of England head coach Trevor Bayliss and selectors James Whitaker and Mick Newell.
He added a match-defining 170 with Liam Dawson who smashed 83 from 68 deliveries with three sixes and five fours.
Ben Duckett gave the North the flying start they needed in reply, racing to a 32-ball half century and sharing a third-wicket stand of 74 with Liam Livingstone.
Dawson claimed the key wicket of Duckett and the Hampshire all-rounder went on to earn figures of two for 46 in his second tidy spell of the series.
Clarke, who hit a half century and top-scored for The North in the opening game, came in at number five and made 27 off 30 balls with one six and two fours.
The 20-year-old was fifth out at 162 in the 24th over, caught by Northeast off Tom Curran who had also dismissed him on Thursday.
Bresnan then hit a fine 74 from 66 balls but the South ran out comfortable winners.
Clarke and The North will now be aiming to avoid a 3-0 whitewash when the series concludes in Abu Dhabi on Tuesday.
Both sides made two changes from the first game, with Tom Alsop and Tim Groenewald replacing Lewis Gregory and Mason Crane for the South, and Josh Poysden and Saqib Mahmood making their North debuts as Mark Wood and Graeme White took a rest.
*Worcestershire's batsmen and bowlers enjoyed two day's match practice against local rivals Warwickshire at the conclusion of their training camp in Abu Dhabi.
On day one Warwickshire scored 157-3 in their permitted 60 overs and Worcestershire replied with 66-3 in their permitted 30 overs.
On day two Worcestershire scored 131-8 in their allotment of 60 overs and Warwickshire totalled 96-4 in their 30 overs of batting.