Tom Fell and Mitchell Santner will be part of the Worcestershire Seconds side who take on Somerset Seconds in two T20 matches at Taunton Vale tomorrow.
Fell is continuing his comeback after completing a third cycle of chemotherapy for cancer in the lymph nodes.
The 22-year-old, who yesterday played club cricket for Wolverhampton against Kidderminster and scored a half century, has returned to full-time training with the County.
Santner will use the two T20 friendlies to hone his skills ahead the launch of the Rapids NatWest T20 Blast campaign against Durham Jets at New Road on Friday (5.30pm start).
The all-rounder also featured in the Rapids T20 friendly against Shropshire at Shifnal on Friday.
He is available for all of the Rapids North Group programme.
Triallist Adeel Shafique will keep wicket after playing purely as a batsman against Warwickshire Seconds at Barnt Green.