Alexei Kervezee and Ross Whiteley sparkled with the bat for Worcestershire Rapids but Derbyshire Falcons reached a 296 target in the Royal London One-Day group match at New Road.
Kervezee struck a free-flowing 77 and dominated a third wicket stand of 115 in 14 overs with Joe Clarke.
Then Whiteley continued in a similar vein by making 61 as Worcestershire were bowled out for 295 in the 50th over.
But a century from Hamish Rutherford and half centuries from Billy Godleman and Wayne Madsen saw the Falcons to victory with 11 balls to spare.
Worcestershire skipper Daryl Mitchell elected to bat after winning the toss on the same pitch as was used for the NatWest T20 Blast clash with Yorkshire Vikings on Thursday.
Tom Kohler-Cadmore (0) was dismissed in the second over when he nicked Ben Cotton to Neil Broom at second slip.
Mitchell collected the first boundary of the innings with a cover-drive at Andy Carter's expense.
Cotton made a second breakthrough when Mitchell (9) was bowled at 17-2 in the eighth over.
Joe Clarke looked in good touch and collected three boundaries in an over from Cotton as Worcestershire reached 40-2 at the end of the first 10 over powerplay.
Kervezee was also quickly into his stride and played with great fluency and freedom as the sun started to break through.
Two superb straight drives off Shiv Thakor by the former Dutch international brought up the 50.
He then lofted spinner Matt Critchley for successive sixes and raced to an excellent half century off 33 balls.
The 100 came up in the 19th over and the century stand between Clarke and Kervezee occupied just 13 overs.
Kervezee struck Thakor for three fours in an over but then three wickets went down for 11 runs.
Thakor ended Kervezee's fine knock by bowling him for 77 off just 50 balls with three sixes and eight fours.
Clarke (44) was run out by Wayne Madsen's throw to keeper Tom Poynton after Brett D'Oliveira turned Alex Hughes on the leg side.
D'Oliveira (6) was bowled by Thakor to leave Worcestershire on 143-5 in the 26th over.
Former Derbyshire player Ross Whiteley and Ben Cox then added 81 in confident manner for the sixth wicket.
Whiteley hit Critchley for three fours in an over and then the left hander's straight six off Hughes raised the 200 in the 37th over.
Cox provided good support before on 27 he was caught at deep mid wicket off Cotton in his first over back in the attack.
Whiteley went to an excellent 50 off 43 balls with one six and six fours.
He deposited Critichley over mid wicket for six but was dismissed lbw to the next delivery attempting a reverse sweep for 61.
Joe Leach made a quickfire 32 from 26 balls with two sixes and two fours before he was bowled by Cotton – his fourth wicket of the innings.
Andy Carter polished off the innings as Ed Barnard (12) holed out to long on and Chris Russell (2) was caught behind.
Cotton finished with 4-43 from 10 overs and Carter 2-38 from 9.4 overs while Critchley conceded 101 runs in his 10 over spell
Derbyshire were kept on a tight rein by Worcestershire's new ball attack of Leach and Jack Shantry and only 32 runs came from the opening 10 overs plus the wicket of Chesney Hughes.
He was run out for seven, short of his ground attempting a second run after an excellent throw from deep point by Whiteley who fieldedsuperbly throughout.
Shantry's opening spell produced the excellent figures of 8-2-19-0 including two successive maidens.
But then Billy Godleman and Hamish Rutherford figured in a partnership of 132 in 22 overs.
It was Mitchell who broke the stand when Godleman on 61 was bowled after he went for a drive.
Rutherford struck seven sixes and six fours in his 74 ball hundred and was seldom troubled.
But Barnard ended his fine knock on 104 when brought back into the attack as Rutherford aimed a pull shot and was bowled at 194-3 in the 36th over.
Wayne Madsen maintained the momentum for Derbyshire and went to his half century off 41 balls with one six and four fours.
He finished unbeaten on 69 from 53 balls with one six and seven fours and was well supported by Neil Broom (45 not out) in an unbroken stand of 104 in 12.2 overs.