Worcestershire will launch their Second Eleven Trophy campaign away to Derbyshire on Tuesday at Alvaston and Boulton Cricket Club.
They will then take on the same opponents in a three-day Championship match at Derby starting the following day.
The county were beaten by four wickets when they faced Somerset in a three-day friendly encounter at Taunton.
Worcestershire resumed the final day on 51-1 – a lead of 63 – and Tom Kohler-Cadmore (47) and Tom Fell (27) extended their partnership to 50 before both were dismissed in quick succession.
Skipper Joe Leach and first innings century-maker Joe Clarke plundered 178 in 16 overs to set up a declaration with the total on 279-3.
Leach hit 90 not out off 57 balls with four sixes and 15 fours and Clarke an unbeaten 84 off 48 balls with four sixes and 13 fours to give him an undefeated match aggregate of 193.
Leach declared at lunch but Alex Barrow scored a career best 168 to help secure victory for Somerset following an opening stand of 157 with Tom Abell in 33 overs.
Leach struck in successive overs but Somerset looked to be coasting at 282-3 with just 10 runs required.
George Rhodes then caught Barrow of the bowling of Chris Russell and picked up two more wickets himself but the home side secured victory.
Worcestershire second innings (overnight 51-1): Kohler-Cadmore c Montgomery b Hoddle 47, Fell lbw Montgomery 27, J. Leach not out 90, Clarke not out 84, Extras 14. Total 279-3 declared (39 overs). Bowling: Burke 1-55, Hoddle 1-42, Montgomery 1-6. FOW continued: 83, 101.
Somerset second innings: Abell c Clarke b Russell 40, Barrow c Rhodes b Russell 168, Waller c Harrison b J. Leach 17, Kilbee lbw J. Leach 0. Burke c Kohler-Cadmore b Rhodes 50, Mellor c Russell b Rhodes 2, Regan not out 7, M. Leach not out 0, Extras 11. Total 295-6 (66.2 overs).
Bowling: Russell 16.2-3-70-2, Cessford 12-0-48-0, J. Leach 10-1-40-2, Choudhry 11-1-45-0, Harrison 5-1-30-0, D'Oliveira 7-0-22-0, Rhodes 5-0-29-2.
FOW: 157, 189, 192, 282, 288, 288.
A reminder that the second eleven Twenty20 game with Glamorgan on May 9 has been switched from New Road to Kidderminster's Chester Road ground.